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1

Activation and degranulation of CAR-T cells using engineered antigen-presenting cell surfaces

Dirar, Qassim, Russell, Teal, Liu, Lumei, Ahn, Sarah, Dotti, Gianpietro, Aravamudhan, Shyam, Conforti, Laura, Yun, Yeoheung, Beavis, Paul A.

Journal:

Year:

2020

File:

PDF, 3.10 MB

2020

2

Eradication of neuroblastoma by T cells redirected with an optimized GD2-specific chimeric antigen receptor and interleukin-15

Chen, Yuhui, Sun, Chuang, Landoni, Elisa, Metelitsa, Leonid S, Dotti, Gianpietro, Savoldo, Barbara

Journal:

Clinical Cancer Research

Year:

2019

Language:

english

File:

PDF, 4.50 MB

english, 2019

3

IMMU-17. TRANSGENIC EXPRESSION OF IL15 IMPROVES ANTIGLIOMA ACTIVITY OF IL13RΑ2-CAR T CELLS

Steffin, David, Prinzing, Brooke, Yi, Zhongzhen, Balyasnikova, Irina, Dotti, Gianpietro, Gottschalk, Stephen, Krenciute, Giedre

Journal:

Year:

2017

Language:

english

File:

PDF, 86 KB

english, 2017

4

Review article Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor

Jena, Bipulendu, Dotti, Gianpietro, Cooper, Laurence J N

Year:

2015

Language:

english

File:

PDF, 237 KB

english, 2015

5

Genetically engineered CAR NK cells display selective cytotoxicity against FLT3-positive B-ALL and inhibit in vivo leukemia growth

Oelsner, Sarah, Waldmann, Anja, Billmeier, Arne, Röder, Jasmin, Lindner, Aline, Ullrich, Evelyn, Marschalek, Rolf, Dotti, Gianpietro, Jung, Gundram, Große-Hovest, Ludger, Oberoi, Pranav, Bader, Peter,

Journal:

International Journal of Cancer

Year:

2019

Language:

english

File:

PDF, 3.67 MB

english, 2019

6

76. Transgenic Expression of IL15 Improves Antiglioma Activity of IL13Rα2-CAR T Cells

Krenciute, Giedre, Balyasnikova, Irina, Dotti, Gianpietro, Gottschalk, Stephen

Journal:

Molecular Therapy

Year:

2016

Language:

english

File:

PDF, 335 KB

english, 2016

7

In situ formed reactive oxygen species–responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy

Wang, Chao, Wang, Jinqiang, Zhang, Xudong, Yu, Shuangjiang, Wen, Di, Hu, Quanyin, Ye, Yanqi, Bomba, Hunter, Hu, Xiuli, Liu, Zhuang, Dotti, Gianpietro, Gu, Zhen

Journal:

Science Translational Medicine

Year:

2018

Language:

english

File:

PDF, 10.66 MB

english, 2018

8

Overcoming the toxicity hurdles of genetically targeted T cells

Casucci, Monica, Hawkins, Robert E., Dotti, Gianpietro, Bondanza, Attilio

Journal:

Cancer Immunology, Immunotherapy

Year:

2015

Language:

english

File:

PDF, 335 KB

english, 2015

9

Integrin targeted oncolytic adenoviruses Ad5-D24-RGD and Ad5-RGD-D24-GMCSF for treatment of patients with advanced chemotherapy refractory solid tumors

Sari Pesonen, Iulia Diaconu, Vincenzo Cerullo, Sophie Escutenaire, Mari Raki, Lotta Kangasniemi, Petri Nokisalmi, Gianpietro Dotti, Kilian Guse, Leena Laasonen, Kaarina Partanen, Eerika Karli, Elina H

Journal:

International Journal of Cancer

Year:

2012

Language:

english

File:

PDF, 919 KB

english, 2012

10

Transgenic expression of IL15 improves antiglioma activity of IL13Ralpha2-CAR T cells but results in antigen-loss variants

Krenciute, Giedre, Prinzing, Brooke L, Yi, Zhongzhen, Wu, Meng-Fen, Liu, Hao, Dotti, Gianpietro, Balyasnikova, Irina V., Gottschalk, Stephen

Journal:

Cancer Immunology Research

Year:

2017

Language:

english

File:

PDF, 1.02 MB

english, 2017

11

GD2-specific CAR T cells encapsulated in an injectable hydrogel control retinoblastoma and preserve vision

Wang, Kai, Chen, Yuhui, Ahn, Sarah, Zheng, Min, Landoni, Elisa, Dotti, Gianpietro, Savoldo, Barbara, Han, Zongchao

Journal:

Year:

2020

File:

PDF, 7.58 MB

2020

12

Extending the Option of CMV-Specific T Cells from the CMV-Seronegative Donor

Hanley, Patrick J., Nikiforow, Sarah, Melenhorst, Jan, Scheinberg, Phillip, Savoldo, Barbara, Dotti, Gianpietro, Rooney, Cliona M., Heslop, Helen E., Shpall, Elizabeth J., Barrett, A. John, Bollard, C

Journal:

Biology of Blood and Marrow Transplantation

Year:

2014

Language:

english

File:

PDF, 53 KB

english, 2014

13

A novel TCR-like CAR with specificity for PR1/HLA-A2 effectively targets myeloid leukemia in vitro when expressed in human adult peripheral blood and cord blood T cells

Ma, Qing, Garber, Haven R., Lu, Sijie, He, Hong, Tallis, Eran, Ding, Xiaoling, Sergeeva, Anna, Wood, Michael S., Dotti, Gianpietro, Salvado, Barbara, Ruisaard, Kathryn, Clise-Dwyer, Karen, John, Lisa

Journal:

Year:

2016

Language:

english

File:

PDF, 1.48 MB

english, 2016

14

Long-term remission in multiply relapsed enteropathy-associated T-cell lymphoma following CD30 CAR T-cell therapy

Voorhees, Timothy J., Ghosh, Nilanjan, Grover, Natalie, Block, Jared, Cheng, Catherine, Morrison, Kaitlin, Ivanova, Anastasia, Dotti, Gianpietro, Serody, Jonathan, Savoldo, Barbara, Beaven, Anne W.

Journal:

Year:

2020

File:

PDF, 1.06 MB

2020

15

Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

Pule, Martin A, Savoldo, Barbara, Myers, G Doug, Rossig, Claudia, Russell, Heidi V, Dotti, Gianpietro, Huls, M Helen, Liu, Enli, Gee, Adrian P, Mei, Zhuyong

Journal:

Nature Medicine

Year:

2008

Language:

english

File:

PDF, 487 KB

english, 2008

16

Fifteen Years of Gene Therapy Based on Chimeric Antigen Receptors: “Are We Nearly There Yet?”

Dotti, Gianpietro, Savoldo, Barbara, Brenner, Malcolm

Journal:

Human Gene Therapy

Year:

2009

Language:

english

File:

PDF, 11.51 MB

english, 2009

17

CARs on Track in the Clinic

Kohn, Donald B, Dotti, Gianpietro, Brentjens, Renier, Savoldo, Barbara, Jensen, Michael, Cooper, Laurence JN, June, Carl H, Rosenberg, Steven, Sadelain, Michel, Heslop, Helen E

Journal:

Molecular Therapy

Year:

2011

Language:

english

File:

PDF, 262 KB

english, 2011

18

T Lymphocytes Are Not Immune

Dotti, Gianpietro

Journal:

Molecular Therapy

Year:

2013

Language:

english

File:

PDF, 256 KB

english, 2013

19

Autologous Designer Antigen-presenting Cells by Gene Modification of T Lymphocyte Blasts With IL-7 and IL-12

Foster, Aaron E., Leen, Ann M., Lee, Timothy, Okamura, Takayuki, Lu, An, Vera, Juan, Atkinson, Rachel, Bollard, Catherine M., Dotti, Gianpietro, Rooney, Cliona M.

Journal:

Journal of Immunotherapy

Year:

2007

Language:

english

File:

PDF, 414 KB

english, 2007

20

Redirecting T cells to Glypican-3 with 4-1BB.ζ CAR results in Th-1 polarization and potent anti-tumor activity

Li, Wenpeng, Guo, Linjie, Rathi, Purva, Marinova, Ekaterina, Gao, Xiuhua, Wu, Meng-Feng, Liu, Hao, Dotti, Gianpietro, Gottschalk, Stephen, Metelitsa, Leonid, Heczey, Andras

Journal:

Human Gene Therapy

Year:

2016

Language:

english

File:

PDF, 1.13 MB

english, 2016

21

T cell homing therapy for reducing regulatory T cells and preserving effector T cell function in large solid tumors

Hu, Jiemiao, Sun, Chuang, Bernatchez, Chantale, Xia, Xueqing, Hwu, Patrick, Dotti, Gianpietro, Li, Shulin

Journal:

Clinical Cancer Research

Year:

2018

Language:

english

File:

PDF, 13.63 MB

english, 2018

22

Transdermal cold atmospheric plasma-mediated immune checkpoint blockade therapy

Chen, Guojun, Chen, Zhitong, Wen, Di, Wang, Zejun, Li, Hongjun, Zeng, Yi, Dotti, Gianpietro, Wirz, Richard E., Gu, Zhen

Journal:

Proceedings of the National Academy of Sciences

Year:

2020

Language:

english

File:

PDF, 1.52 MB

english, 2020

23

Adenovector-induced expression of human-CD40-ligand (hCD40L) by multiple myeloma cells: A model for immunotherapy

Gianpietro Dotti, Barbara Savoldo, Satoshi Takahashi, Tatiana Goltsova, Michael Brown, Donna Rill, Cliona Rooney, Malcolm Brenner

Journal:

Experimental Hematology

Year:

2001

Language:

english

File:

PDF, 194 KB

english, 2001

24

Changes in Chemokine Receptor Expression of Regulatory T Cells After Ex Vivo Culture

Chakraborty, Rikhia, Rooney, Cliona, Dotti, Gianpietro, Savoldo, Barbara

Journal:

Journal of Immunotherapy

Year:

2012

Language:

english

File:

PDF, 526 KB

english, 2012

25

512. Tumor-Associated Macrophages Via Up-Regulation of PD1 Ligands Protect Neuroblastoma from Immunotherapy With NKT Cells Expressing GD2-Specific Chimeric Antigen Receptor

Liu, Daofeng, Courtney, Amy N., Heczey, Andras, Marinova, Ekaterina, Tian, Gengwen, Guo, Linjie, Gao, Xiuhua, Dotti, Gianpietro, Metelitsa, Leonid S.

Journal:

Molecular Therapy

Year:

2015

Language:

english

File:

PDF, 331 KB

english, 2015

26

Comprehensive Approach for Identifying the T Cell Subset Origin of CD3 and CD28 Antibody–Activated Chimeric Antigen Receptor–Modified T Cells

Schmueck-Henneresse, Michael, Omer, Bilal, Shum, Thomas, Tashiro, Haruko, Mamonkin, Maksim, Lapteva, Natalia, Sharma, Sandhya, Rollins, Lisa, Dotti, Gianpietro, Reinke, Petra, Volk, Hans-Dieter, Roone

Journal:

The Journal of Immunology

Year:

2017

Language:

english

File:

PDF, 3.03 MB

english, 2017

27

Engineering PD-1-Presenting Platelets for Cancer Immunotherapy

Zhang, Xudong, Wang, Jinqiang, Chen, Zhaowei, Hu, Quanyin, Wang, Chao, Yan, Junjie, Dotti, Gianpietro, Huang, Peng, Gu, Zhen

Journal:

Year:

2018

Language:

english

File:

PDF, 6.22 MB

english, 2018

28

In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

Chen, Qian, Wang, Chao, Zhang, Xudong, Chen, Guojun, Hu, Quanyin, Li, Hongjun, Wang, Jinqiang, Wen, Di, Zhang, Yuqi, Lu, Yifei, Yang, Guang, Jiang, Chen, Wang, Jun, Dotti, Gianpietro, Gu, Zhen

Journal:

Nature Nanotechnology

Year:

2018

Language:

english

File:

PDF, 3.52 MB

english, 2018

29

Cellular Immunity to Epstein-Barr Virus in Liver Transplant Recipients Treated with Rituximab for Post-Transplant Lymphoproliferative Disease

Barbara Savoldo, Cliona M. Rooney, Ruben E. Quiros-Tejeira, Yvette Caldwell, Hans-Joachim Wagner, Timothy Lee, Milton J. Finegold, Gianpietro Dotti, Helen E. Heslop, John A. Goss

Journal:

American Journal of Transplantation

Year:

2005

Language:

english

File:

PDF, 140 KB

english, 2005

30

Adverse events following infusion of T cells for adoptive immunotherapy: a 10-year experience

Cruz, Conrad Russell, Hanley, Patrick J., Liu, Hao, Torrano, Vicky, Lin, Yu-Feng, Arce, James A., Gottschalk, Stephen, Savoldo, Barbara, Dotti, Gianpietro, Louis, Chrystal U., Leen, Ann M., Gee, Adria

Journal:

Year:

2010

Language:

english

File:

PDF, 131 KB

english, 2010

31

An Inducible Caspase 9 Suicide Gene to Improve the Safety of Mesenchymal Stromal Cell Therapies

Carlos Almeida Ramos, Zahra Asgari, Enli Liu, Eric Yvon, Helen E. Heslop, Clio M. Rooney, Malcolm K. Brenner, Gianpietro Dotti

Journal:

Year:

2010

Language:

english

File:

PDF, 744 KB

english, 2010

32

Chimeric antigen receptor (CAR)-engineered lymphocytes for cancer therapy

Ramos, Carlos A, Dotti, Gianpietro

Journal:

Expert Opinion on Biological Therapy

Year:

2011

Language:

english

File:

PDF, 655 KB

english, 2011

33

Mesenchymal Stromal Cells for Linked Delivery of Oncolytic and Apoptotic Adenoviruses to Non-small-cell Lung Cancers

Hoyos, Valentina, Del Bufalo, Francesca, Yagyu, Shigeki, Ando, Miki, Dotti, Gianpietro, Suzuki, Masataka, Bouchier-Hayes, Lisa, Alemany, Ramon, Brenner, Malcolm K

Journal:

Molecular Therapy

Year:

2015

Language:

english

File:

PDF, 8.92 MB

english, 2015

34

507. Chondroitin Sulfate Proteoglycan 4 (CSPG4)-Redirected T Cells Eliminate Glioblastoma-Derived Neurospheres

Pellegatta, Serena, Savoldo, Barbara, Su, Chuang, Ferrone, Soldano, Finocchiaro, Gaetano, Dotti, Gianpietro

Journal:

Molecular Therapy

Year:

2016

Language:

english

File:

PDF, 298 KB

english, 2016

35

C-10. Inducible Caspase-9 Suicide Gene Controls Adverse Effects from Alloreplete T Cells after Haploidentical Stem Cell Transplantation

Zhou, Xiaoou, Dotti, Gianpietro, Krance, Robert A., Martinez, Caridad, Kamble, Rammurti T., Naik, Swati, Durett, April G., Dakhova, Olga, Savoldo, Barbara, Di Stasi, Antonio, Spencer, David M., Lin, Y

Journal:

Molecular Therapy

Year:

2015

Language:

english

File:

PDF, 265 KB

english, 2015

36

CD30-Redirected Chimeric Antigen Receptor T Cells Target CD30+ and CD30- Embryonal Carcinoma via Antigen-dependent and Fas/FasL Interactions

Hong, Lee Kyung, Chen, Yuhui, Smith, Christof C, Montgomery, Stephanie A, Vincent, Benjamin G., Dotti, Gianpietro, Savoldo, Barbara

Journal:

Cancer Immunology Research

Year:

2018

Language:

english

File:

PDF, 3.74 MB

english, 2018

37

Leucocyte alkaline phosphatase identifies terminally differentiated normal neutrophils and its lack in chronic myelogenous leukaemia is not dependent on p210 tyrosine kinase activity

Gianpietro Dotti, Enrico Garattini, Gianmaria Borleri, Kensaku Masuhara, Orietta Spinelli, Tiziano Barbui, Alessandro Rambaldi

Journal:

British Journal of Haematology

Year:

1999

Language:

english

File:

PDF, 235 KB

english, 1999

38

Inducible Caspase 9 Suicide Gene to Improve the Safety of Allodepleted T Cells after Haploidentical Stem Cell Transplantation

Siok-Keen Tey, Gianpietro Dotti, Cliona M. Rooney, Helen E. Heslop, Malcolm K. Brenner

Journal:

Biology of Blood and Marrow Transplantation

Year:

2007

Language:

english

File:

PDF, 919 KB

english, 2007

39

Selective depletion of a minor subpopulation of B-chronic lymphocytic leukemia cells is followed by a delayed but progressive loss of bulk tumor cells and disease regression

Aaron E Foster, Fatma V Okur, Ettore Biagi, An Lu, Gianpietro Dotti, Eric Yvon, Barbara Savoldo, George Carrum, Michael Andreeff, Margaret A Goodell, Helen E Heslop, Malcolm K Brenner

Journal:

Molecular Cancer

Year:

2009

Language:

english

File:

PDF, 1.02 MB

english, 2009

40

Chimeric antigen receptors (CARs) from bench-to-bedside

Savoldo, Barbara, Dotti, Gianpietro

Journal:

Immunology Letters

Year:

2013

Language:

english

File:

PDF, 409 KB

english, 2013

41

TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy

Grada, Zakaria, Hegde, Meenakshi, Byrd, Tiara, Shaffer, Donald R, Ghazi, Alexia, Brawley, Vita S, Corder, Amanda, Schönfeld, Kurt, Koch, Joachim, Dotti, Gianpietro, Heslop, Helen E, Gottschalk, Stephe

Journal:

Molecular Therapy — Nucleic Acids

Year:

2013

Language:

english

File:

PDF, 1.60 MB

english, 2013

42

A ″Non-Fratricidal″ αβ-T Cell Receptor That Targets Survivin Expressed By Hematological Malignancies

Arber, Caroline, Feng, Xiang, Abhyankar, Harshal, Heslop, Helen E., Brenner, Malcolm K., Barth, Patrick, Dotti, Gianpietro, Savoldo, Barbara

Journal:

Biology of Blood and Marrow Transplantation

Year:

2014

Language:

english

File:

PDF, 52 KB

english, 2014

43

Design and development of therapies using chimeric antigen receptor-expressing T cells

Dotti, Gianpietro, Gottschalk, Stephen, Savoldo, Barbara, Brenner, Malcolm K.

Journal:

Immunological Reviews

Year:

2014

Language:

english

File:

PDF, 378 KB

english, 2014

44

266. Gene Modification of T Antigen Presenting Cells for the Induction of Antitumor Immunity

Foster, Aaron E., Leen, Ann M., Lee, Timothy, Vera, Juan, Dotti, Gianpietro, Rooney, Cliona M.

Journal:

Molecular Therapy

Year:

2006

Language:

english

File:

PDF, 99 KB

english, 2006

45

T Cells Expressing Constitutively Active Akt Resist Multiple Tumor-associated Inhibitory Mechanisms

Sun, Jiali, Dotti, Gianpietro, Huye, Leslie E, Foster, Aaron E, Savoldo, Barbara, Gramatges, Maria M, Spencer, David M, Rooney, Cliona M

Journal:

Molecular Therapy

Year:

2010

Language:

english

File:

PDF, 615 KB

english, 2010

46

HG-108MULTISPECIFIC CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELLS OVERCOME INTER-PATIENT TUMOR HETEROGENEITY AND EXHIBIT ENHANCED ANTITUMOR FUNCTIONALITY IN THE TREATMENT OF GLIOBLASTOMA

Bielamowicz, Kevin, Fousek, Kristen, Byrd, Tiara, Mukherjee, Malani, Aware, Nikita, Chow, Kevin, Krebs, Simone, Yi, Zhongzhen, Dotti, Gianpietro, Sumazin, Pavel, Gottschalk, Stephen, Hegde, Meena, Ahm

Journal:

Year:

2016

Language:

english

File:

PDF, 31 KB

english, 2016

47

PD-1 Blockade Cellular Vesicles for Cancer Immunotherapy

Zhang, Xudong, Wang, Chao, Wang, Jinqiang, Hu, Quanyin, Langworthy, Benjamin, Ye, Yanqi, Sun, Wujin, Lin, Jing, Wang, Tianfu, Fine, Jason, Cheng, Hao, Dotti, Gianpietro, Huang, Peng, Gu, Zhen

Journal:

Advanced Materials

Year:

2018

Language:

english

File:

PDF, 2.89 MB

english, 2018

48

Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells

Chen, Qian, Hu, Quanyin, Dukhovlinova, Elena, Chen, Guojun, Ahn, Sarah, Wang, Chao, Ogunnaike, Edikan A., Ligler, Frances S., Dotti, Gianpietro, Gu, Zhen

Journal:

Advanced Materials

Year:

2019

Language:

english

File:

PDF, 6.02 MB

english, 2019

49

Comparison of two CD40-ligand/interleukin-2 vaccines in patients with chronic lymphocytic leukemia

Okur, Fatma Visal, Yvon, Eric, Biagi, Ettore, Dotti, Gianpietro, Carrum, George, Heslop, Helen, Mims, Martha P., Fratantoni, Joseph C., Peshwa, Madhusudan V., Li, Linhong

Journal:

Year:

2011

Language:

english

File:

PDF, 428 KB

english, 2011

50

Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells

Chen, Qian, Hu, Quanyin, Dukhovlinova, Elena, Chen, Guojun, Ahn, Sarah, Wang, Chao, Ogunnaike, Edikan A., Ligler, Frances S., Dotti, Gianpietro, Gu, Zhen

Journal:

Advanced Materials

Year:

2019

File:

PDF, 6.02 MB

2019

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